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We unravel inflammatory networks to understand homeostasis 

and fight inflammatory disorders


We study innate immune cell biology, with the goal of understanding the earliest events that initiate immunity to infection, or drive the development of immune-mediated diseases. Our primary research is centered on the study of Pattern Recognition Receptor (PRR) signaling pathways, which initiate all immune responses and activate a network of transcription factors that orchestrate the inflammatory response. We seek to understand the events that initiate protective immunity in response to infection (to bacteria, i.e., Escherichia coli, viruses, i.e., IAV and SARS-CoV-2, and also to fungi, i.e., Candida albicans) and tissue injury, and to harness the immune response to develop new therapeutic ways of intervention to solve unmet clinical challenges. Our current strategy for achieving these goals is to integrate findings derived from a combination of omics technologies, in vitro signaling studies, and in vivo murine models, apply this information to refine our hypotheses, and create models that can explain - and predict - the

pathophysiology of inflammation in humans.


Fall 2022 Semester Course

Innate immunity and viral infections of the lung

Oct-Dec, 2022

in Harvard Medical School 


Keystone Meeting “Inflammation in the Lung: Friend or Foe in Viral Infections?”

April 23-27, 2023

Snowbird, UT

Invited Speaker

GRC Meeting
“2023 Phagocytes Gordon Research Conference”


June 4-9, 2023

Waterville Valley, NH

Invited  Speaker

GRC Meeting

“2023 Atherosclerosis Gordon Research Conference"

June 18-23, 2023

Castelldefels, Spain



If we can except those isolated and miraculous moments fate can bestow on a man, loving your work (unfortunately, the privilege of a few) represents the best, most concrete approximation of happiness on earth. But this is a truth not many know.

Primo Levi, The Monkey’s Wrench, 1978.


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Division of Immunology

Division of Gastroenterology

Boston Children’s Hospital

The Karp Family Research Building 10.217

One Blackfan Circle, Boston, MA 02115

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