We study innate immune cell biology, with the goal of understanding the earliest events that initiate immunity to infection, or drive the development of immune-mediated diseases. Our primary research is centered on the study of Pattern Recognition Receptor (PRR) signaling pathways, which initiate all immune responses and activate a network of transcription factors that orchestrate the inflammatory response. We seek to understand the events that initiate protective immunity in response to infection (to bacteria, i.e., Escherichia coli, viruses, i.e., IAV and SARS-CoV-2, and also to fungi, i.e., Candida albicans) and tissue injury, and to harness the immune response to develop new therapeutic ways of intervention to solve unmet clinical challenges. Our current strategy for achieving these goals is to integrate findings derived from a combination of omics technologies, in vitro signaling studies, and in vivo murine models, apply this information to refine our hypotheses, and create models that can explain - and predict - the

pathophysiology of inflammation in humans.

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