I trained with Paola Ricciardi-Castagnoli, receiving my Ph.D. in Immunology at the University of Roma-Tor Vergata (Rome, Italy). I then performed postdoctoral training with Francesca Granucci at the University of Milano-Bicocca (Milan, Italy) and with Dr. Jonathan C. Kagan at Boston Children’s Hospital (Boston, USA). I became Assistant Professor at Harvard University, Faculty of Medicine, in 2015 and in 2020 I was promoted to Associate Professor (Boston, USA). Since 2021 I hold the Boston Children’s Hospital Chair in the Field of Immunology at Harvard University, Faculty of Medicine. I am currently Research Faculty and Principal Investigator at Boston Children’s Hospital, Division of Immunology and Division of Gastroenterology (Boston, USA). Since 2020 I hold an Investigators in the Pathogenesis of Infectious Disease Award at the Burroughs Wellcome Fund and since 2021 I am a Lloyd J. Old STAR Investigator at the Cancer Research Institute.
Since 2008 I sit in the Committee of the Ph.D. Program in Translational Medicine at the University of Milano – Bicocca (Milan, Italy). Since 2015 I am a Member of the Immunology Program at the Harvard Medical School, I am a member of the Admission Committee of the Immunology Ph.D. Program and of the HMS Committee on Immunology Seminar Series.
My lab is funded by several grants from NIH (NIAID and NIDDK) and other private Foundations. I have published more than 75 papers on international journals.
The impact of the findings of my Lab in the scientific community is also highlighted by the numerous invited talks in plenary section of well-established international meetings such as: FASEB Conference; Cytokines; Digestive Disease Week (DDW); NIH Interferon Lambda Meeting; Crohn's and Colitis Congress; Gordon Research Conference; SLB conference; AAI Meeting, etc. Also, the innovative findings of the lab were disseminated through numerous seminars at local (i.e.: MGH, BCH, HSPH, Harvard Immunology), regional (i.e.: UMASS), national (i.e.: Mount Sinai, ETSU, UC-Irvine, …), and international (i.e.: BRFAA in Greece, Crick Institute and King’s College in UK, SRH in Italy) locations.
Invited reviews to disseminate our findings were written for: The Journal of Experimental Medicine; Annual Reviews in Immunology; Current Opinion in Immunology; The Journal of Leukocyte Biology; Frontiers in Immunology; Seminars in Immunology; and other peer reviewed journals.
CURRENT TEAM MEMBERS
Marco Di Gioia - Ph.D.
Marco is an Instructor at Harvard Medical School and core scientist at Harvard Digestive Diseases Center (HDDC) where he offers training and consultation for cell metabolic analysis. He obtained his Ph.D. in Translational Medicine at University of Milano-Bicocca, studying Natural Killer (NK) cell and dendritic cell activation. In 2015 he joined the Zanoni lab studying how endogenous oxidized phospholipids, released during infectious and non-infectious conditions, sustain and enhance the inflammatory responses of phagocytes. His major interest is to elucidate the molecular mechanisms by which host-derived stressors rewire the metabolic status of both immune and non-immune cells and how this impacts the progression of chronic pathologies, such as atherosclerosis, obesity and colitis.
Valentina Poli - Ph.D.
Valentina completed her M.Sc. in Biology and her Ph.D in Translational Medicine at the University of Milano-Bicocca, Italy. She joined the Zanoni lab as a graduate student working on the interaction of platelets and neutrophils in sepsis development. Also, she investigates the molecular mechanisms involved in NETosis induction during infections.
When not in the lab, Valentina likes following her passion for photography, and taking care of her indoor garden.
Sreya Ghosh - Ph.D.
Sreya completed her B.Sc. and M.Sc. (Biochemistry) from University of Calcutta, India and received her Ph.D. (Immunology & Microbiology) from the University of Massachusetts Medical School, USA where she trained with Dr. Katherine A. Fitzgerald. In the Zanoni lab, she works on harnessing the capabilities of type III interferons in infections and cancer.
Outside of the lab, Sreya enjoys long drives, reading fiction, and experimenting with different cuisines.
Carl Britto - M.D., Ph.D.
Carl earned his medical degree from St. John's Medical College, India and subsequently pursued his doctoral studies at the University of Oxford, UK on a Rhodes scholarship. He studied the molecular epidemiology of enteric fever in South Asia under Dr. Andrew Pollard, director of the Oxford Vaccine Group. He is currently a pediatric resident on the integrated research pathway, part of the Boston Combined Residency Program. In the Zanoni lab, he works on delineating the role of inflammatory chemokines in severe pneumonia and biomarkers of severe outcomes of pneumonia.
Outside of the lab, Carl enjoys running, biking and stand-up comedy.
David Hoytema - M.D., Ph.D.
David performed his PhD in Immunology at Utrecht University in the Van Wijk lab and at the Rockefeller University in the Mucida lab. He completed pediatrics residency at Boston Children’s Hospital and Harvard Medical School concurrent with research at Harvard Medical School in the Kirchhausen lab, and in the Zon lab. He joined the Immunology Division at Boston Children's Hospital and Harvard Medical School and is jointly supervised by Drs. Nigrovic and Zanoni.
Océane Dufies - Ph.D.
Océane obtained her PhD in immunology and microbiology at University Côte d’Azur in France. During her PhD in Laurent Boyer’s lab she studied the detection of RhoGTPases-activating toxins by the innate immune system. She joined the Zanoni lab in 2022 as a research fellow and is interested in the inflammatory response triggered by endogenous ligands.
During her free time she loves climbing and cooking.
Kautilya Jena - Ph.D.
Kautilya joined the Zanoni lab as a post-doctoral research fellow in March 2022. He completed
his Ph.D. from DBT-Institute of Life Sciences, India in 2021 where he focused on the
mechanism of protein aggregation biology and its implication in neurodegeneration and cancer.
After his Ph.D. he worked as research associate and contributed to elucidate the innate immune molecular mechanisms that control inflammation and viral infections. In the Zanoni lab he focuses on the development of new vaccine adjuvant formulations based on microbial ligands. He is also involved in deciphering the role of type III interferons in mucosal biology. Besides research, he loves travelling, watching movies, and playing football.
Daniel Böhmer – M.D.
Daniel studied Medicine at the LMU and TU in Munich. From 2015 to 2017 he performed his MD thesis in the lab of Lars Koenig and Max Schnurr in the Division of Clinical Pharmacology at the LMU university hospital on cell death induction in tumor cells by RLR-ligands. He continued working there as a postdoc from 2018 to 2019 focusing on interferon biology. Since 2019 he is doing his residency in Internal Medicine and Gastroenterology in the Department of Medicine II at the university hospital of the LMU. He joined the Zanoni lab in 2022 to work on innate immune pathways related to intestinal inflammation.
When not in the lab, Daniel enjoys spending time with his family, playing tennis, ski touring and very mediocre surfing.
PAST TEAM MEMBERS
Principal Investigator at CIML, France
MS student at University of Milano-Bicocca
Antonino Lo Cascio, M.S.
PhD student at Humanitas University, Italy
Ph.D. student at University Hospital Zurich, Switzerland
Ph.D. student at San Raffaele Hospital, Italy
Fellow at San Raffaele Hospital, Italy
Associate Director, Preclinical Discovery and Development at Generate Biomedicines
Faculty at Xi'an Jiaotong University, China
Intern at FMI in Basel, Switzerland.
Fellow at Humanitas University, Italy