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Ivan Zanoni

I trained with Paola Ricciardi-Castagnoli, receiving my Ph.D. in Immunology at the University of Roma-Tor Vergata (Rome, Italy). I then performed postdoctoral training with Francesca Granucci at the University of Milano-Bicocca (Milan, Italy) and with Dr. Jonathan C. Kagan at Boston Children’s Hospital (Boston, USA). I became Assistant Professor at Harvard University, Faculty of Medicine, in 2015 and in 2020 I was promoted to Associate Professor (Boston, USA). I am currently Research Faculty and Principal Investigator at Boston Children’s Hospital, Division of Immunology and Division of Gastroenterology (Boston, USA). Since 2020 I hold an Investigators in the Pathogenesis of Infectious Disease Award at the Burroughs Wellcome Fund.

Since 2008 I sit in the Committee of the Ph.D. Program in Translational Medicine at the University of Milano – Bicocca (Milan, Italy). Since 2015 I am a Member of the Immunology Program at the Harvard Medical School, I am a member of the Admission Committee of the Immunology Ph.D. Program and of the HMS Committee on Immunology Seminar Series.

My lab is funded by several grants from NIH (NIAID and NIDDK) and other private Foundations. I have published more than 75 papers on international journals. 

The impact of the findings of my Lab in the scientific community is also highlighted by the numerous invited talks in plenary section of well-established international meetings such as: FASEB Conference; Cytokines; Digestive Disease Week (DDW); NIH Interferon Lambda Meeting; Crohn's and Colitis Congress; Gordon Research Conference; SLB conference; AAI Meeting, etc. Also, the innovative findings of the lab were disseminated through numerous seminars at local (i.e.: MGH, BCH, HSPH, Harvard Immunology), regional (i.e.: UMASS), national (i.e.: Mount Sinai, ETSU, UC-Irvine, …), and international (i.e.: BRFAA in Greece, Crick Institute and King’s College in UK, SRH in Italy) locations. 

Invited reviews to disseminate our findings were written for: The Journal of Experimental Medicine; Annual Reviews in Immunology; Current Opinion in Immunology; The Journal of Leukocyte Biology; Frontiers in Immunology; Seminars in Immunology; and other peer reviewed journals. 

CURRENT TEAM MEMBERS
Achille Broggi

Achille Broggi - Ph.D.

Achille obtained his PhD in Translational Medicine in 2012, in the lab of Francesca Granucci at the University of Milan Bicocca. There he studied peripheral T cell tolerance and the role of the transcription factor NFAT in phagocytes. He then moved to Boston in 2015 and joined Ivan’s lab as a research fellow to study the role of type III interferon in mucosal immune responses.
In the lab he uncovered a new immune-modulatory function of IFN-λ, which inhibits neutrophil activation and protects mucosal barriers during intestinal acute inflammation. He also contributed to describe a detrimental role for IFN-λ during tissue repair in viral pneumonia.
An Instructor since 2018, Achille is now following his interest in type III interferon responses as key regulators of mucosal biology and, in particular, in the regulation of the intestinal mucosal barrier.

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Marco Di Gioia - Ph.D.

Marco is an Instructor at Harvard Medical School and core scientist at Harvard Digestive Diseases Center (HDDC) where he offers training and consultation for cell metabolic analysis. He obtained his Ph.D. in Translational Medicine at University of Milano-Bicocca, studying Natural Killer (NK) cell and dendritic cell activation. In 2015 he joined the Zanoni lab studying how endogenous oxidized phospholipids, released during infectious and non-infectious conditions, sustain and enhance the inflammatory responses of phagocytes. His major interest is to elucidate the molecular mechanisms by which host-derived stressors rewire the metabolic status of both immune and non-immune cells and how this impacts the progression of chronic pathologies, such as atherosclerosis, obesity and colitis.

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Valentina Poli - Ph.D.

Valentina completed her M.Sc. in Biology and her Ph.D in Translational Medicine at the University of Milano-Bicocca, Italy. She joined the Zanoni lab as a graduate student working on the interaction of platelets and neutrophils in sepsis development. Also, she investigates the molecular mechanisms involved in NETosis induction during infections.

When not in the lab, Valentina likes following her passion for photography, and taking care of her indoor garden.

Francesco Borriello

Francesco.Borriello - M.D., Ph.D.

Francesco joined the lab in 2018 as research fellow to study how innate immune signals shape antibody immunodominance to viral glycoproteins and their implications for anti-viral vaccine design. Previously he was research fellow in the laboratory of Dr. Ofer Levy (Boston Children’s Hospital, USA) to work on vaccine adjuvant discovery and development. He obtained his MD (2011) at the University of Campania Luigi Vanvitelli (Italy), then completed his training in allergy and clinical immunology (2017) and received his PhD in clinical and experimental medicine (2020) at the University of Naples Federico II (Italy).

Sreya Ghosh

Sreya Ghosh - Ph.D.

Sreya completed her B.Sc. and M.Sc. (Biochemistry) from University of Calcutta, India and received her Ph.D. (Immunology & Microbiology) from the University of Massachusetts Medical School, USA where she trained with Dr. Katherine A. Fitzgerald. In the Zanoni lab, she works on harnessing the capabilities of type III interferons in infections and cancer.

Outside of the lab, Sreya enjoys long drives, reading fiction, and experimenting with different cuisines.

Benedetta Sposito

Benedetta Sposito - M.S.

Benedetta first joined the lab as a Master's student in 2017 working on type III IFNs in the context of respiratory superinfections. She is now a PhD student and her research is focused on host innate immunity at mucosal surfaces.

She loves playing cards and karaoke nights.

Carl Britto

Carl Britto - M.D., Ph.D.

Carl earned his medical degree from St. John's Medical College, India and subsequently pursued his doctoral studies at the University of Oxford, UK on a Rhodes scholarship. He studied the molecular epidemiology of enteric fever in South Asia under Dr. Andrew Pollard, director of the Oxford Vaccine Group. He is currently a pediatric resident on the integrated research pathway, part of the Boston Combined Residency Program. In the Zanoni lab, he works on delineating the role of inflammatory chemokines in severe pneumonia and biomarkers of severe outcomes of pneumonia.

Outside of the lab, Carl enjoys running, biking and stand-up comedy. 

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Calogero Carlino - D.M.D.

Calogero graduated in Dentistry from the University of Palermo, Italy. He worked as a general dentist in private practice and later as a Contact Tracer and CovidHub doctor at C.R. Bollate, Milan. Calogero has worked as a Bioinformatician at CNTE, Niguarda Hospital, Milan. Outside of academia and healthcare, Calogero collaborates in his family's farm and as an IT and 3D printing consultant at a local startup. He is fascinated by the fusion of science and digital arts and believes that the integration between distant scientific fields are fundamental for the advancement of knowledge. Calogero is always ready to cook and share a Sicilian dinner, to share experiences and learn from people of different cultures and backgrounds.

PAST TEAM MEMBERS
Haiyun Li

Haiyun Li,

Ph.D.

Faculty at Xi'an Jiaotong University, China

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Marcella Franco,

M.S.

Intern at FMI in Basel, Switzerland.

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Niccolo Coianiz,

M.S.

Fellow at Humanitas University, Italy

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Marco Raffaelli,

M.S.

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Fabio Balzarini,

M.S.

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Antonino Lo Cascio

Antonino Lo Cascio, M.S.

PhD student at Humanitas University, Italy

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Elena Parietti,

M.S.

Ph.D. student at University Hospital Zurich, Switzerland

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L. Lacanfora,

M.S.

Ph.D. student at San Raffaele Hospital, Italy 

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Alessia Neri,

M.S.

Fellow at San Raffaele Hospital, Italy